Egypt star Mohamed Salah is the reigning player of the season and will be bidding to pick up his fifth golden boot as he forms a new-look front line for the Reds alongside big-money signings Hugo Ekitike and Florian Wirtz.
A number of fellow African stars have secured high-profile transfers of their own, while there are new arrivals from countries including DR Congo, Morocco, Mozambique and Senegal.
Meanwhile, 50 players from the continent could have their Premier League campaigns interrupted by the 2025 Africa Cup of Nations (Afcon), which runs from 21 December to 18 January.
BBC Sport Africa casts an eye over some of the players settling in to new teams and looking to make an impression over the coming nine months.
Can Mbeumo restore United to former glories?
Cameroon international Bryan Mbeumo was the subject of the biggest deal involving an African player in the close season, joining Manchester United for an initial £65m ($87m).
The 25-year-old forward scored 20 league goals and registered seven assists for Brentford last season but now faces a step up at "the club of his dreams".
United are in a rebuilding phase under boss Ruben Amorim after finishing 15th, their worst-ever performance in the Premier League era.
Mbeumo will face instant pressure to perform alongside fellow big-money arrivals Matheus Cunha and Benjamin Sesko - with United having spent £200m ($271m) on the attacking trio - even if there is no European football for the Old Trafford outfit.
His off-field passion for playing the piano and chess are well known, and now United needs Mbeumo to hit the right notes and execute his best strategies on the pitch.
The Ghana midfielder impressed in his first season in east London but his second campaign was underwhelming as he struggled to adapt to Graham Potter's wing-back system.
Kudus' glittering performances at Ajax had made him one of European football's hottest properties and Spurs will be expecting the 24-year-old to rediscover that form.
Featuring in the Champions League again was one reason for his switch to north London, while the Black Stars man was also encouraged by the opportunity to play for new Spurs coach Thomas Frank, who has made the switch from Brentford.
"From where [Frank] has come from, and seeing the amount of talent he has developed to become great players, it's a big sign as to why I wanted to work under him," said Kudus.
With Spurs legend Son Heung-Min departing and James Maddison set to miss most of the season through injury, Kudus could find himself in a pivotal role from the offset.